Welcome to the Urethral Stricture Support blog. These pages are intended to assist those with questions regarding the disease, expected outcomes, resources, and emotional and informational support. AT NO TIME WILL MEDICAL ADVICE OF ANY KIND BE RENDERED. With your permission, your commentary may be included within the topics discussed within this forum. Moderators Cesar and Tim have a combined 50 years (celebrating a half-century of difficult urination) of experience in living with, dealing with, and overcoming what is broadly considered a disease with a high rate of morbidity. We have experienced every common surgical and instrumental "fix"/"repair" offered including the implantation of the Urolume Endoprosthesis. Both moderators have experience with the Urolume Endoprosthesis. To the best of our knowledge, this is the first and only such support group anywhere. Please, do not be afraid or embarrassed to ask any question with regards to your diagnosis. We encourage you to discuss any and all information offered within this blog with your Urologist. A proactive and informed patient usually receives the best care.

With your help, and well-considered posts, the information gleaned from this site should help the countless scores of males aged 18 and over who are encountering the diagnosis of "Urethral Stricture".


DISCLAIMER: We do not provide medical advice. We disseminate information relevant to urethral stricture disease. While we encourage research (and participation in research), we endorse no medication or treatment protocols. PLEASE FEEL FREE TO CONTACT US WITH SPECIFIC QUESTIONS @ urethralstrictures[no spam] at yahoo dot com

Friday, November 25, 2011

Whatever happened to URISED?? a.k.a. What REALLY happened to Urised??

While doing research into which topics to best cover within this blog, I was "wishin" that I had a few Urised tabs around to ward-off some minor burning that I've been encountering. So,,,, I picked up the phone, called my daughter, an M.D. , and asked if one of her associates could call in a script for 30-or-so. "Shure", she replied, only to follow with a phone call ten minutes later stating: "it's not being manufactured anymore, do you want Pyridium instead"? HELL, NO!, I replied, I like to pee "peeeecock blue" (my licensed variant in spelling), not rust-orange,,, I ABSOLUTELY HATE PHENAZOPYRIDINE!!

So, being the intrepid research scientist that I am (seriously, I contracted to NASA for two years), I did some digging. Here's what was discovered:

Interstitial Cystitis (ICN) Bladder Pain Support Forum 

Just wanted to put it out there for those that use it- that Urised has been discontinued by the manufacturer (Amerifit) and according to them it is permanent. I liked Urised the best out of all of the antispasmodics.  This was effective in late 2007

There is a near-substitute, Prosed, which has had it's own problems. So, here's the rest of the story:


As mentioned above, Urised was produced by a company called "Amerifit Brands", which apparently purchased it's former manufacturer, American Urological sometime after 1999.  Everything was copasetic until 07 November 2007, when this occurred. (well worth linking to, and they sent it via FEDEX!)

Shortly thereafter, the remaining stock was sold off, and Urised was destined to never be seen again.

Oh - wait, THERE'S MORE!!


Anyone having to purchase medications containing pseudoephedrine can tell you of the rigamarole that you now have to go through. A driver's License, passport, birth certificate, iris scan, and third-degree interrogation seem to be commonplace because of the pseudoephedrine controls initiated at the state level. This law has made it more difficult for diversion of the substance, which is a precursor to methamphetamine, to be purchased by clandestine manufacturers of illicit meth, thus making manufacture of meth almost impossible, correct??

Well, it turns out that Urised contained a chemical called methanamine, which metabolizes into formaldehyde in the urinary tract. Methanamine is also a precursor to methamphetmine, and a DEA Schedule C-I Controlled Substance, which made Urised a possible target for meth labs as a source of the base ingredient. It seems the formulation of Urised is easily separated by the backyard chemist. Prosed uses a proprietary process to sequester the methanamine, making its separation darn near impossible. Rumors were, that in order to continue the manufacture of Urised, Amerifit would have been required to also sequester the Methanamine.



A little more research yielded a treasure-trove of info on Amerifit Brands, and their "alleged" quality control issues. It turns out that Amerifit is/was one of the leading manufacturers of non-prescription (which often contained ephedra) diet pills and programs (can you say "Accutrim"?). Much of this mess started with the push to restrict the sale of ephedra and pseudoephedrine in 2004 (election season), and concluded with the restriction of phenylproponalamine (PPA) and ephedra under the  Combat Methamphetamine Epidemic Act of 2005. Whatever occurred, in 2010 Martek Biosciences Corporation followed through with the purchase of Amerifit Brands.

People who have various lower urinary tract disorders no longer have the peace of mind (without the large out-of-pocket cost) and relief offered by Urised for more than fifty years!

Say thank you to your local meth addict!

That's all she wrote folks, it's ProsedDS® or nothing, and that a damn shame....

BTW: I settled for its more expensive half-brother, ProsedDS®. <---hey, it's better than  nothing!

UPDATE: 22 JULY 2012

The makers of ProsedDS® had a few QC Hiccups in September of 2011, and as of this writing, it has pretty much disappeared from pharmacy stock. Hyophen®, a similar, and slightly less expensive alternative (again, without the atropine liability of Urised®, and at a slightly lesser expense than ProsedDS® appeared in our pharmacies earlier this year. The jury is still out on it's effectiveness, however, Hyophen® provides an alternative to phenazopyridine. A much welcomed alternative.

UPDATE: 30 JULY 2012

The initial information that we received regarding Hyophen® was that it was intended to be a similar performer to ProsedDS® and Urelle®, but would be available at lower pricing; that information was partially in error. To my astonishment, I paid $69.04USD for THIRTY of them. My apologies for not verifying pricing before publishing a post, you have my assurances that this will not happen again. You may have noticed a survey request for information from those taking Hyophen®. This request was made after receiving an email from a urologist who had questions about the performance of the medication. The results were informative, but not sufficient for a conclusion in any direction.  ProsedDS® is off of the market; Urelle® and Hyophen® are both of similar composition and price. Let's just say that you had better have a good third party pharmacy plan should your urologist prescribe either medication.  We are looking for foreign alternatives.

We have also heard that two of the ingredients in the medications have become extremely expensive, and difficult to source.

Per: Moderator Tim

The advantages of in-home uroflowmetry

In the mid-1980's, my urologist urged me to use a device for uroflowmetry which looked like a small rectangular plastic fish-tank prior to commencing each office visit. The urine flowed through small "trap doors" which activated at four stages. The urine measured at each stage was compared to a chart that provided a mean-value which was charted for comparison to a base-line obtained soon after each urethral surgery. Eventually, I was prompted to purchase one of these now-extinct "manual urine flow gauges" (which lasted ten years) to track thrice-weekly measurements which really did help by forcing me to go for a dilitation/urethrotomy, or whatever - while the stricture was in a more open state, allowing for a "kinder instrumentation" or easier urethrotomy.

Ask your urologist if he or she feels this type of tracking would be beneficial in your case, there is a device made in the U.K. known as the Uflow urine meter which is not easily available in North America. With shipping, the cost is around $23.00 U.S.  A base-line (in-office) uroflowmetric study will have to be done for comparison to your initial results.  The savings in discomfort should be well worth the investment!
 Per: Moderator Tim

Manufacturer's information page